Blood glucose recovery following allogenetic hematopoietic stem cell transplantation in patients with hematological diseases complicated with diabetes mellitus

doi:10.3969/j.issn.2095-4344.2014.41.015

Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (41): 6645-6648.doi: 10.3969/j.issn.2095-4344.2014.41.015

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Blood glucose recovery following allogenetic hematopoietic stem cell transplantation in patients with hematological diseases complicated with diabetes mellitus

Feng Kai¹, Xu Yi-wei¹, Ye Fu-guang¹, Jiang Min², Chen Hu², Shi Bing-yi¹

¹Department of Cellular Therapy, PLA Organ Transplantation Centre, the 309^th Hospital of PLA, Beijing 100091, China; ²Department of Transplantation, the 307^th Hospital of PLA, Beijing 100071, China

Revised:2014-07-02 Online:2014-10-01 Published:2014-10-01
Contact: Shi Bing-yi, Master, Chief physician, Professor, Doctoral supervisor, Department of Cellular Therapy, PLA Organ Transplantation Centre, the 309th hospital of PLA, Beijing 100091, China
About author:Feng Kai, M.D., Associate chief physician, Associate investigator, Department of Cellular Therapy, PLA Organ Transplantation Centre, the 309th hospital of PLA, Beijing 100091, China
Supported by:
the Capital Health Development and Research Special Program, No. 2011-5007-03

Abstract

Abstract:

BACKGROUND: Recent studies have shown that the large-dose regular insulin therapy used to control blood glucose levels can cause 50% of patients suffering from vascular, optic nerve and kidney complications. Previous results from authors exhibit that when allogeneic hematopoietic stem cell transplantation is applied for treatment of leukemia, diabetic symptoms in patients disappear. Dose it prompt that allogeneic hematopoietic stem cell transplantation is an effective therapy for treatment of diabetes mellitus?

OBJECTIVE: To explore the feasibility of hematopoietic stem cell transplantation for treatment of diabetes mellitus.

METHODS: A retrospective analysis was done regarding the data of patients with hematological diseases complicated with diabetes mellitus who underwent allogenetic hematopoietic stem cell transplantation. Four patients with acute lymphocyte leukemia, chronic myelogenous leukemia, aplastic anemia, and myolodysplastic syndromes, respectively, were complicated with diabetes mellitus. Conditioning regimen was cyclophosphamide+ total body irradiation protocol. Cyclosporin A and short-term methotrexate were used for graft-versus-host disease prophylaxis. Blood glucose was controlled by oral hypoglycemic drugs or insulin injections before transplantation.

RESULTS AND CONCLUSION: All the four patients were successfully engrafted. Fasting glucose level of the four patients recovered at 4-6 months after hematopoietic stem cell transplantation (without hypoglycemic drugs). One patient died of leukemia relapse after 12 months of hematopoietic stem cell transplantation. The other three patients had disease-free survival until the time of follow-up.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: stem cells, hematopoietic stem cell transplantation, hematologic diseases, diabetes mellitus, blood glucose

CLC Number:

R394.2

Feng Kai, Xu Yi-wei, Ye Fu-guang, Jiang Min, Chen Hu, Shi Bing-yi. Blood glucose recovery following allogenetic hematopoietic stem cell transplantation in patients with hematological diseases complicated with diabetes mellitus[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(41): 6645-6648.

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Blood glucose recovery following allogenetic hematopoietic stem cell transplantation in patients with hematological diseases complicated with diabetes mellitus

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